Diffusion-weighted Imaging

Acquisition parameters

Three types of diffusion sequences were employed in three different sessions, respectively:

  • High-resolution (1.3mm isotropic, 60 directions) acquisitions with \(B=1500\) or \(B=3000\).

Acquisition parameters for high-resolution diffusion imaging.

Parameter

Value

Sequence

diff_dw60_TE76

TR

7000 ms

TE

76 ms

Flip angle

90 deg

Refocusing flip angle

180 deg

FOV

240 mm

Slice thickness

1.30 mm

Number of slices

112 slices

GRAPPA iPAT

2

Multiband accel. factor

2

Echo spacing

0.71 ms

BW

1598 Hz/Px

Phase partial Fourier

6/8

b-values

[1500, 3000] s/mm2

  • Multi-shell (1.3mm isotropic, 20 directions) acquisitions for multiple B-values ranging from 300 to 3000 in steps of 300.

Acquisition parameters for multi-shell diffusion imaging.

Parameter

Value

Sequence

diff_dw26_TE76

TR

7000 ms

TE

76 ms

Flip angle

90 deg

Refocusing flip angle

180 deg

FOV

240 x 240 mm

Matrix

128 x 128

Slice thickness

1.30 mm, 112 slices, 1.30 mm isotropic

Multiband accel. factor

2

Echo spacing

0.71 ms

BW

1598 Hz/Px

Phase partial Fourier

6/8

b-values

[0, 300, 600, 900, 1200, 1500,

1800, 2100, 1400, 2700, 3000] s/mm2

  • Two low-resolution acquisitions (2mm, 20 directions) used for screening.

Acquisition parameters for screening.

Parameter

Value

Sequence

diff_screening_2mmiso

TR

9000 ms

TE

66,00 ms

Flip angle

90 deg

Refocusing flip angle

180 deg

FOV

240 x 240 mm

Matrix

128 x 128

Slice thickness

2 mm isotropic, 70 slices

Multiband accel. factor

1

Echo spacing

0,54 ms

BW

2192 Hz/Px

Phase partial Fourier

6/8

b-values

0, 1500 s/mm2

Parameter

Value

Sequence

diff_dw20_MB

TR

5700 ms

TE

79,40 ms

Flip angle

90 deg

Refocusing flip angle

180 deg

FOV

240 x 240 mm

Matrix

160 x 160

Slice thickness

1,5 mm isotropic, 94 slices

Multiband accel. factor

2

Echo spacing

0,65 ms

BW

1838 Hz/Px

Phase partial Fourier

6/8

b-values

0, 1500 s/mm2